We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A narrative review of proteinuria and albuminuria as clinical biomarkers in children.
- Authors
Larkins, Nicholas G; Teixeira‐Pinto, Armando; Craig, Jonathan C; Teixeira-Pinto, Armando
- Abstract
Proteinuria is an important biomarker commonly used to detect and manage kidney disease in children. There are now a variety of methods available to measure urinary protein loss, and physicians are faced with several contrasting strategies: 24-h or timed collection versus spot samples (first-morning or random), measurement of total urinary protein versus selective measurement of urinary albumin, unadjusted urine protein concentration versus protein-to-creatinine ratio and the use of dipstick versus laboratory-based methods. In this review, we will discuss the advantages and disadvantages of these different approaches. We will then summarise the evidence base for proteinuria as a clinical biomarker in different settings, including discussion of the current and potential role of measuring low-level albuminuria. Finally, we will highlight gaps in the literature and opportunities for further research into proteinuria among children.
- Subjects
BIOLOGICAL tags; PEDIATRIC nephrology; ALBUMINURIA; KIDNEY disease diagnosis; PROTEINURIA
- Publication
Journal of Paediatrics & Child Health, 2019, Vol 55, Issue 2, p136
- ISSN
1034-4810
- Publication type
journal article
- DOI
10.1111/jpc.14293