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- Title
Three siblings with self-resolving congenital hyperthyrotropinaemia secondary to thyrotropin receptor blocking antibodies.
- Authors
Azzopardi, Peter; Forrester, Mike; Ehtisham, Sarah
- Abstract
Thyrotropin receptor blocking antibodies are a rare cause of hyperthyrotropinaemia and more rarely of congenital hypothyroidism. We report a case of hyperthyrotropinaemia but normal thyroid hormone in the newborn of a mother with hypothyroidism treated with thyroxine. Two older siblings had similar high thyrotropin and normal thyroid function in the newborn period which did not require hormone treatment and resolved spontaneously. Demonstration of thyrotropin receptor antibodies in the child confirmed our diagnosis. Our case was not treated with thyroid replacement hormone and has remained biochemically euthyroid, with thyrotropin levels returning to normal over a period of months.
- Subjects
THYROID disease diagnosis; HUMAN abnormalities; THYROTROPIN; NEONATAL diseases; IMMUNOGLOBULINS
- Publication
Journal of Paediatrics & Child Health, 2010, Vol 46, Issue 7/8, p439
- ISSN
1034-4810
- Publication type
Article
- DOI
10.1111/j.1440-1754.2009.01687.x