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- Title
Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes.
- Authors
Carrillo-Sepúlveda, Maria Alícia; Ceravolo, Graziela S.; Fortes, Zuleica Bruno; Carvalho, Maria Helena; Tostes, Rita C.; Laurindo, Francisco R.; Webb, R. Clinton; Barreto-Chaves, Maria Luiza M.
- Abstract
Aims: Thyroid hormone (TH) rapidly relaxes vascular smooth muscle cells (VSMCs). However, the mechanisms involved in this effect remain unclear. We hypothesize that TH-induced rapid vascular relaxation is mediated by VSMC-derived nitric oxide (NO) production and is associated with the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signalling pathway.
- Subjects
THYROID hormones; VASCULAR smooth muscle; MUSCLE cells; NITRIC oxide; PROTEIN kinases
- Publication
Cardiovascular Research, 2010, Vol 85, Issue 3, p560
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1093/cvr/cvp304