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- Title
Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease.
- Authors
Brugts, Jasper Jan; Isaacs, Aaron; Boersma, Eric; van Duijn, Cock M.; Uitterlinden, Andre G.; Remme, Willem; Bertrand, Michel; Ninomiya, Toshiharu; Ceconi, Claudio; Chalmers, John; MacMahon, Stephen; Fox, Kim; Ferrari, Roberto; Witteman, Jacqueline C.M.; Danser, A.H. Jan; Simoons, Maarten L.; de Maat, Moniek P.M.
- Abstract
Aims: The efficacy of angiotensin-converting enzyme (ACE)-inhibitors in stable coronary artery disease (CAD) may be increased by targeting the therapy to those patients most likely to benefit. However, these patients cannot be identified by clinical characteristics. We developed a genetic profile to predict the treatment benefit of ACE-inhibitors exist and to optimize therapy with ACE-inhibitors.
- Publication
European Heart Journal, 2010, Vol 31, Issue 15, p1854
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/ehq169