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- Title
Intracoronary bone marrow cell transfer after myocardial infarction: 5-year follow-up from the randomized-controlled BOOST trial.
- Authors
Meyer, Gerd P.; Wollert, Kai C.; Lotz, Joachim; Pirr, Jens; Rager, Ulrike; Lippolt, Peter; Hahn, Andreas; Fichtner, Stephanie; Schaefer, Arnd; Arseniev, Lubomir; Ganser, Arnold; Drexler, Helmut
- Abstract
Aims: We assessed whether a single intracoronary infusion of autologous bone marrow cells (BMCs) can have a sustained impact on left ventricular ejection fraction (LVEF) in patients after ST-elevation myocardial infarction (STEMI). In the BOne marrOw transfer to enhance ST-elevation infarct regeneration (BOOST) trial, 60 patients with STEMI and successful percutaneous coronary intervention were randomized to a control and a cell therapy group. As previously reported, BMC transfer led to an improvement of LVEF by 6.0% at 6 months (P = 0.003) and 2.8% at 18 months (P = 0.27).
- Publication
European Heart Journal, 2009, Vol 30, Issue 24, p2978
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/ehp374