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- Title
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.
- Authors
G. Giovannoni; G. Pryce; M.L. Cuzner; Z. Ahmed; D. Baker; D.J.R. Hankey; S.J. Jackson; J.L. Croxford; J.M. Pocock; C. Ledent; A. Petzold; A.J. Thompson
- Abstract
Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that is triggered by inflammatory attack of the CNS. As yet there is no satisfactory treatment. Using experimental allergic encephalo myelitis (EAE), an animal model of multiple sclerosis, we demonstrate that the cannabinoid system is neuroprotective during EAE. Mice deficient in the cannabinoid receptor CB1 tolerate inflammatory and excito toxic insults poorly and develop substantial neurodegeneration following immune attack in EAE. In addition, exogenous CB1 agonists can provide significant neuroprotection from the consequences of inflammatory CNS disease in an experimental allergic uveitis model. Therefore, in addition to symptom management, cannabis may also slow the neurodegenerative processes that ultimately lead to chronic disability in multiple sclerosis and probably other diseases.
- Subjects
MULTIPLE sclerosis; NEURODEGENERATION; ENCEPHALOMYELITIS
- Publication
Brain: A Journal of Neurology, 2003, Vol 126, Issue 10, p2191
- ISSN
0006-8950
- Publication type
Article