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- Title
NSAID-induced urticaria/angioedema does not evolve into chronic urticaria: a 12-year follow-up study.
- Authors
Doña, I.; Blanca‐López, N.; Torres, M. J.; Gómez, F.; Fernández, J.; Zambonino, M. A.; Monteseirín, F. J.; Canto, G.; Blanca, M.; Cornejo‐García, J. A.
- Abstract
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequent medicaments involved in drug hypersensitivity reactions, with NSAID-induced urticaria/angioedema ( NIUA) being the most frequent clinical entity. The natural evolution of NIUA has been suggested to lead to chronic urticaria ( CU) in an important proportion of patients, such that NIUA may therefore precede CU. Our aim was to verify whether these entities are related by following up a large cohort of patients with NIUA as well as a control group over a long period of time. Methods The study comprised three groups: (i) patients with a confirmed history of NIUA (more than two episodes with at least two different NSAIDs or positive drug provocation tests), (ii) patients with more than two episodes of urticaria/angioedema to a single NSAID with good tolerance to a strong COX-1 inhibitor and/or evidence by in vivo tests supporting specific IgE antibodies to the drug (single NSAID-induced urticaria/angioedema, SNIUA), and (iii) controls who tolerated NSAIDs. All cases in the three groups were followed up over a period of 12 years. Results There were 190 patients with NIUA (64.6% female; mean age 43.71 ± 15.82 years, 110 with SNIUA, and 152 controls. At the 12-year evaluation, 12 patients with NIUA (6.15%) had developed CU over a 1- to 8-year period. Similar proportions were seen in SNIUA and controls. Conclusions Nonsteroidal anti-inflammatory drugs-induced urticaria/angioedema does not seem to precede the onset of CU over the medium term. Further research including a longer follow-up is necessary to verify this observation.
- Subjects
DRUG side effects; NONSTEROIDAL anti-inflammatory agents; URTICARIA; ANGIONEUROTIC edema; FOLLOW-up studies (Medicine)
- Publication
Allergy, 2014, Vol 69, Issue 4, p438
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.12335