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- Title
Dendritic cells present neuromuscular blocking agent-related epitopes to T cells from allergic patients.
- Authors
Aubert, N.; Mertes, P. M.; Janaszak, M.; Moneret-Vautrin, D. A.; Laxenaire, M. C.; Kanny, G.; Lavaud, F.; Bernard, J.
- Abstract
This article focuses on a case-control study to assess whether dendritic cells (DC) from patients having presented an anaphylactic reaction to an neuromuscular blocking agents (NMBA) during anesthesia were able to present the incriminated drug and to stimulate T cells. Monocytes and T lymphocytes were purified from fresh heparinized blood. Several mechanisms could explain how DC might process and present the incriminated NMBA. Ten patients sensitized to an NMBA and eight control subjects were involved in the study.
- Subjects
DENDRITIC cells; NEUROMUSCULAR blocking agents; EPITOPES; T cells; MONOCYTES; ANAPHYLAXIS; ANESTHESIA
- Publication
Allergy, 2004, Vol 59, Issue 9, p1022
- ISSN
0105-4538
- Publication type
Other
- DOI
10.1111/j.1398-9995.2004.00486.x