We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Predictive and prognostic value of v-set and transmembrane domain-containing 1 expression in monocytes for coronary artery disease.
- Authors
Xiao-Fei Wang; Meng-Cheng Xu; Cheng-Yu Mao; En-Zhou; Qing He; Xing-Qian Qu; Yu-Qi Fan; Chang-Qian Wang; Jun-Feng Zhang; Wang, Xiao-Fei; Xu, Meng-Cheng; Mao, Cheng-Yu; He, Qing; Qu, Xing-Qian; Fan, Yu-Qi; Wang, Chang-Qian; Zhang, Jun-Feng
- Abstract
The aim of this study was to investigate the correlation between v-set and transmembrane domain-containing 1 (VSTM1) expression and incidence of major adverse cardiac events (MACE) in patients with coronary heart disease (CHD). A total of 310 patients were divided into a non-acute coronary syndrome (non-ACS) group (containing the stable angina group, and the asymptomatic coronary artery diseaseand other patients group) and an ACS group (containing unstable angina and acute myocardial infarction patients). Monocytic VSTM1 expression levels (assessed via average fluorescence intensity derived from antibody binding to VSTM1) in each group were detected and analyzed. The cut-off value of monocytic VSTM1 expression to predict the onset of ACS and MACE was confirmed. VSTM1 expression in monocytes from the ACS group was lower than that of the non-ACS group. The incidence of MACEs in the high VSTM1-expression group was much less than that of those in the low VSTM1 expression group at the 1 year follow-up stage. VSTM1 expression had an independent-inversed association with increased incidence of MACE and ACS. VSTM1 expression in monocytes may help to predict the occurrence of ACS in patients with CHD, and moreover it may provide the means to evaluate MACE prognosis during CHD patient follow-up.
- Subjects
MYOCARDIAL infarction diagnosis; MYOCARDIAL infarction; ACUTE coronary syndrome; PROGNOSIS; CORONARY artery disease; RESEARCH funding; MONOCYTES
- Publication
Reviews in Cardiovascular Medicine, 2021, Vol 22, Issue 3, p1009
- ISSN
1530-6550
- Publication type
journal article
- DOI
10.31083/j.rcm2203110