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- Title
Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer.
- Authors
Liang Hu; Hai-Yang Chen; Jian Cai; Yu Zhang; Chen-Ye Qi; Hui Gong; Yan-Xia Zhai; Hao Fu; Guang-Zhen Yang; Chun-Fang Gao; Hu, Liang; Chen, Hai-Yang; Cai, Jian; Zhang, Yu; Qi, Chen-Ye; Gong, Hui; Zhai, Yan-Xia; Fu, Hao; Yang, Guang-Zhen; Gao, Chun-Fang
- Abstract
<bold>Background: </bold>Aberrant expression of serine threonine tyrosine kinase 1 (STYK1) has been reported in several human malignancies including colorectal cancer (CRC). However, the prognostic significance of STYK1 expression in CRC remains unknown.<bold>Methods: </bold>STYK1 protein expression in paraffin-embedded CRC specimens was determined immunohistochemically. The correlation of STYK1 expression with clinicopathologic features was assessed in a cohort containing 353 patients with primary CRC. Kaplan-Meier and Cox proportional regression analyses were used to evaluate the association between STYK1 expression and patients' survival.<bold>Results: </bold>STYK1 expression was frequently up-regulated in CRC clinical samples at the protein levels and was significantly associated with tumor differentiation grade (p = 0.030), lymph node metastasis (p = 0.004), TNM stage (p = 0.007) and patient death (p < 0.001). Kaplan-Meier analysis indicated that patients with high intratumoral STYK1 expression had a significantly shorter disease-specific survival (DSS) than those with low expression (p < 0.001). Importantly, high levels of STYK1 protein predicted poor DSS for both stage II (p < 0.001) and stage III (p = 0.004) patients. Furthermore, multivariate analyses revealed that STYK1 protein expression was an independent prognostic indicator for both stage II (hazard ratio [HR], 2.472; p = 0.001) and stage III (HR, 2.001; p = 0.004) patients.<bold>Conclusions: </bold>Our results suggest that increased STYK1 protein expression correlates with disease progression and metastasis and may serve as a predictor of poor survival in CRC.
- Subjects
SERINE/THREONINE kinases; COLON cancer prognosis; TUMOR markers; PROTEIN expression; KAPLAN-Meier estimator; MULTIVARIATE analysis
- Publication
BMC Cancer, 2015, Vol 15, Issue 1, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-015-1285-y