We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Botulinum toxin in multiple sclerosis.
- Authors
Kabus, Christian; Hecht, Martin; Japp, Gudrun; Jost, Wolfgang H.; Pöhlau, Dieter; Stuckrad-Barre, Sebastian; Winterholler, Martin
- Abstract
Local administration of botulinum toxin (BoTx) inhibits presynaptic acetylcholine release. All cholinergically innervated muscles and glands can be paralyzed accordingly. Studies on the application of BoTx in multiple sclerosis have shown good results for focal spasticity, in particular, of the extremities. The first promising data were published on bladder disorders, especially with regard to detrusor sphincter dyssynergia and detrusor hyperreflexia. Hyperhidrosis, hypersalivation and proctologic symptoms might be other areas of application. Approval, however, has been greatly restricted which limits the therapeutic range of use.
- Subjects
BOTULINUM toxin; MULTIPLE sclerosis; SPASTICITY; HYPERHIDROSIS; NEUROTOXIC agents
- Publication
Journal of Neurology, 2006, Vol 253, pI16
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-006-1106-y