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- Title
Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice
- Authors
Michaud, Jason; Kohno, Masataka; Proia, Richard L.; Hla, Timothy
- Abstract
Abstract: Sphingosine-1-phosophate, generated from the phosphorylation of sphingosine by sphingosine kinase enzymes, is suggested to function as an intracellular second messenger for inflammatory mediators, including formyl peptide, C5a, and Fc. More recently, a role for sphingosine kinases during inflammation has also been proposed. Here we show that sphingosine kinase 1 knockout mice exhibit normal inflammatory cell recruitment during thioglycollate-induced peritonitis and that sphingosine kinase 1-null neutrophils respond normally to formyl peptide. In the collagen-induced arthritis model of rheumatoid arthritis, sphingosine kinase 1 knockout mice developed arthritis with normal incidence and severity. Our findings show that sphingosine kinase 1 is dispensable for inflammatory responses and support the need for more extensive studies of sphingosine kinases in inflammation.
- Subjects
SPHINGOLIPIDS; ETHANOLAMINES; ARTHRITIS; LIPIDS
- Publication
FEBS Letters, 2006, Vol 580, Issue 19, p4607
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2006.07.035