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- Title
Comparative simulations of aquaporin family: AQP1, AQPZ, AQP0 and GlpF
- Authors
Hashido, Masanori; Ikeguchi, Mitsunori; Kidera, Akinori
- Abstract
Abstract: Molecular dynamics simulations were performed for four members of the aquaporin family (AQP1, AQPZ, AQP0, and GlpF) in the explicit membrane environment. The single-channel water permeability, p f, was evaluated to be GlpF∼AQPZ>AQP1≫AQP0, while their relative pore sizes were GlpF≫AQP1>AQPZ≫AQP0. This relation between p f and pore size indicates that water permeability was determined not only by the channel radius, but also another competing factor. Analysis of water dynamics revealed that this factor was the single-file nature of water transport.
- Subjects
MOLECULAR dynamics; MEMBRANE proteins; PERMEABILITY; CAPILLARITY
- Publication
FEBS Letters, 2005, Vol 579, Issue 25, p5549
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.09.018