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- Title
Expression of mismatch repair proteins in urothelial carcinoma of the urinary bladder.
- Authors
Mohamedali, Rasheeda; Adhya, Amit; Mandal, Swarnendu; Mitra, Suvradeep; Adhya, Amit K
- Abstract
<bold>Background: </bold>Urothelial carcinoma of the urinary bladder (UCUB) is a frequently diagnosed malignancy. Mismatch repair (MMR), a proofreading machinery of the DNA, prevents tumorigenesis. The role of MMR deficiency in UCUB in eastern Indian population is not known.<bold>Methods: </bold>Immunohistochemistry panel for MLH1, PMS2, MSH2, and MSH6 (MMR proteins) was performed on the biopsy specimens of UCUB (N=100).<bold>Results: </bold>MMR deficiency by immunohistochemistry was demonstrated in two cases (2%). One case showed deficiency of MSH2 and MSH6 and the other case showed the deficiency of all four mismatch proteins. Both cases showed high-grade invasive urothelial carcinoma by histomorphology.<bold>Conclusion: </bold>The prevalence of MMR deficiency by immunohistochemistry is 2% in eastern Indian population.
- Publication
Indian Journal of Cancer, 2022, Vol 59, Issue 2, p279
- ISSN
0019-509X
- Publication type
Case Study
- DOI
10.4103/ijc.IJC_225_21