We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation
- Authors
Clayton, Alison L.; Mahadevan, Louis C.
- Abstract
That signalling pathways, particularly the mitogen-activated protein kinase cascades, elicit modification of chromatin proteins such as histone H3 by phosphorylation and/or acetylation concomitant with gene activation is now well established. The picture that is emerging is one of a complex and dynamic pattern of multiple modifications at the H3 tail. Here, we review the inducible gene systems where H3 modifications have been reported and re-evaluate the controversy as to the kinase(s) that phosphorylates it as well as the proposed coupling between H3 phosphorylation and acetylation.
- Subjects
PROTEIN kinases; PHOSPHORYLATION
- Publication
FEBS Letters, 2003, Vol 546, Issue 1, p51
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)00451-4