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- Title
FFAs and adipokine-mediated regulation of hsa-miR-143 expression in human adipocytes.
- Authors
Zhu, Lingling; Shi, Chunmei; Ji, Chenbo; Xu, Guangfeng; Chen, Ling; Yang, Lei; Fu, Ziyi; Cui, Xianwei; Lu, Yibing; Guo, Xirong
- Abstract
Accumulating evidence suggests that microRNAs (miRNAs) play an important role in regulating the pathways in adipose tissue that control processes such as adipogenesis, insulin resistance, and inflammation. MiR-143 is a well-characterized miRNA involved in adipogenesis and may be involved in regulating insulin resistance. Free fatty acids (FFAs) and adipokines, such as tumor necrosis factor-α (TNF-α), leptin, resistin, and interleukin-6 (IL-6), have already been identified as main regulators of obesity and insulin sensitivity. Therefore, we studied the effects of these inflammatory cytokines on the expression of miR-143. FFAs, resistin, and leptin downregulated miR-143 expression in human adipocytes, whereas TNF-α and IL-6 had little effect on miR-143 expression. These results suggest that the expression of miR-143 is affected by a variety of factors that are related to insulin sensitivity. Therefore, miR-143 may be an important mediator in the development of obesity-related insulin resistance.
- Subjects
FATTY acids; HORMONE regulation; ADIPOKINES; GENE expression; MICRORNA; FAT cells; ADIPOSE tissues
- Publication
Molecular Biology Reports, 2013, Vol 40, Issue 10, p5669
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-013-2668-2