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- Title
Interleukin 1 beta −511 C/T gene polymorphism and susceptibility to febrile seizures: a meta-analysis.
- Authors
Wu, Zhen-Qiang; Sun, Liang; Sun, Ye-Huan; Ren, Cizao; Jiang, Yu-Hong; Lv, Xiao-Ling
- Abstract
One previous meta-analysis found no evidence that interleukin 1 beta (IL-1β) −511 gene polymorphism was associated with febrile seizures (FS) by pooling a limited number of studies. However, it is necessary for the meta-analysis to reevaluate the relationship with more recent findings. Electronic databases were systematically searched for studies published before June 2011. Pooled odds ratios (OR) and 95% confidence interval (CI) were estimated by means of a genetic model free approach. Subgroup and sensitivity analyses were also performed. All statistical analyses were conducted using Stata 9.0. A total of eight studies, 728 FS cases and 1,223 controls, met the selection criteria. The results show a significant association between IL-1β −511 C/T gene polymorphism and FS (recessive genetic model TT vs. CC + CT: OR = 1.361, 95% CI: 1.065-1.738, P = 0.014). Subgroup analyses show a significant association in Asia (OR = 1.394, 95% CI: 1.005-1.935, P = 0.047), but not in Europe (OR = 1.387, 95% CI: 0.750-2.565, P = 0.298). IL-1β −511 C/T gene polymorphism may play a role in susceptibility to FS, especially in Asia. Geographic differences may be a critical factor in the risk of FS.
- Subjects
INTERLEUKIN-1; GENETIC polymorphism research; DISEASE susceptibility; SPASMS; MOLECULAR biology; GENETICS
- Publication
Molecular Biology Reports, 2012, Vol 39, Issue 5, p5401
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-011-1340-y