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- Title
Silica‐Based Nanoparticles as Drug Delivery Vehicles for Prostate Cancer Treatment.
- Authors
Tiburcius, Steffi; Krishnan, Kannan; Yang, Jae‐Hun; Hashemi, Fatemeh; Singh, Gurwinder; Radhakrishnan, Deepika; Trinh, Hoang Trung; Verrills, Nicole M.; Karakoti, Ajay; Vinu, Ajayan
- Abstract
Prostate cancer (PCa) is one of the most commonly diagnosed cancers and is the fifth common cause of cancer‐related mortality in men. Current methods for PCa treatment are insufficient owing to the challenges related to the non‐specificity, instability and side effects caused by the drugs and therapy agents. These drawbacks can be mitigated by the design of a suitable drug delivery system that can ensure targeted delivery and minimise side effects. Silica based nanoparticles (SBNPs) have emerged as one of the most versatile materials for drug delivery due to their tunable porosities, high surface area and tremendous capacity to load various sizes and chemistry of drugs. This review gives a brief overview of the diagnosis and current treatment strategies for PCa outlining their existing challenges. It critically analyzes the design, development and application of pure, modified and hybrid SBNPs based drug delivery systems in the treatment of PCa, their advantages and limitations.
- Subjects
DRUG carriers; PROSTATE cancer; DRUG side effects; CANCER treatment; DIAGNOSIS; DRUG delivery systems
- Publication
Chemical Record, 2021, Vol 21, Issue 6, p1535
- ISSN
1527-8999
- Publication type
Article
- DOI
10.1002/tcr.202000104