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- Title
Palifermin for prevention of oral mucositis in allogeneic hematopoietic stem cell transplantation: a single-institution retrospective evaluation.
- Authors
Nguyen, Diana; Shayani, Sepideh; Palmer, Joycelynne; Dagis, Andrew; Forman, Stephen; Epstein, Joel; Spielberger, Ricardo; Nguyen, Diana T; Forman, Stephen J
- Abstract
<bold>Purpose: </bold>The purpose of this study is to assess the impact of palifermin on oral mucositis (OM) and its sequelae in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) who were conditioned with fractionated total body irradiation (FTBI) and etoposide.<bold>Methods: </bold>This retrospective chart review study compared the effect of palifermin on the development of OM in patients who received this agent during an allo-HSCT (n = 99) to those who did not (n = 30). The primary end points were severity and duration of OM. Secondary end points included requirements for opioids, total parenteral nutrition (TPN), and intensive oral care; incidence of infection; length of hospital stay; and overall survival.<bold>Results: </bold>There was no significant difference in the incidence of all grades of OM, but incidence of severe OM was decreased in palifermin-exposed patients (34 vs 80 %, p < 0.0001). In patients who developed OM (all grades), the median duration of OM was shorter in palifermin-exposed patients (13 vs 18 days, p = 0.0001); there was no difference in the median duration of severe OM. Patients who received palifermin used less opioids and required a shorter duration of intensive oral care. There was no difference in duration of TPN, incidence of infection, length of hospital stay, and overall survival.<bold>Conclusions: </bold>Our findings demonstrated a significant benefit with the use of palifermin for allo-HSCT recipients who were conditioned with FTBI and etoposide. Palifermin can potentially improve quality of life for this patient population and reduce complications and resources used during the transplant process. A randomized clinical trial is required to confirm these results.
- Subjects
MUCOSITIS; GRAFT versus host disease; HEMATOPOIETIC stem cell transplantation; DISEASE complications; TOTAL body irradiation; DISEASE incidence; PREVENTION; GROWTH factors; ETOPOSIDE; LENGTH of stay in hospitals; PARENTERAL feeding; QUALITY of life; RADIOTHERAPY; RETROSPECTIVE studies; STOMATITIS; THERAPEUTICS
- Publication
Supportive Care in Cancer, 2015, Vol 23, Issue 11, p3141
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-015-2688-7