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- Title
Prevalence and Risk Factors for Death with Graft Function among Egyptian Kidney Transplant Recipients in Mansoura.
- Authors
Abu Gharbia, Mostafa Gamal; Hendy, Yasser Abdelmonem; Refaie, Ayman Fathy; salah, Ahmed Mohamed
- Abstract
Background: Death with graft function (DWGF) is an important cause of long-term loss of grafts and patients. In this study, we investigated clinical characteristics and causes of DWGF among kidney transplant recipients in Mansoura from 2002 to 2019. Methods: From March 2002 to December 2018, 1,499 living donor renal transplants were done in Mansoura. Their data were retrospectively analyzed. Out of 285 reported deaths, 193 patients died with good graft function without the need for dialysis. Results: Death with graft function occurred in about 27% of kidney transplant recipients at a mean age of 36 +10.7 years. Males were 140 (72.5%). They reached end-stage renal disease (ESRD) secondary to GN in 14, PN in 35, PCK in 7, and nephrosclerosis in 12 patients. 125 patients had acute rejections (64.8%). Post-transplant hypertension occurred in 115 patients (59.5%), DM in 44 patients (22.9%), infections in 99 (51.5%), hepatic complications in 44 (22.9%), and malignancy in 25 patients (13%). Fatal infections in 60 patients (31.3%) were the main causes of death followed by cardiovascular causes in 29 patients (15.2%), liver cell failure in 20 patients (10.7%), and malignancy in 9 patients (4.6%). The mean serum creatinine at the last follow-up was 2 ± 0.6 mg/dl. Conclusions: In our study, DWGF constitutes of 27% of total graft loss. The most typical causes were fatal infections and CVS disease, respectively. DWGF develops due to co-morbid medical illness, pre-transplant dialysis, and other transplantation-related factors. Understanding different causes of death are mandatory to improve long-term outcomes.
- Subjects
KIDNEY transplantation; CHRONIC kidney failure; COMORBIDITY; LIVER cells; CAUSES of death
- Publication
Zagazig University Medical Journal, 2024, Vol 30, p100
- ISSN
1110-1431
- Publication type
Article
- DOI
10.21608/ZUMJ.2021.55359.2074