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- Title
Maternal SARS-CoV-2 Infection at Delivery Increases IL-6 Concentration in Umbilical Cord Blood.
- Authors
Kosińska-Kaczyńska, Katarzyna; Rebizant, Beata; Czeszko-Paprocka, Hanna; Bojdo, Agata; Przybylski, Maciej; Chaberek, Katarzyna; Lewandowska, Agnieszka; Szymusik, Iwona; Brawura-Biskupski-Samaha, Robert
- Abstract
Background: SARS-CoV-2 infection in pregnant women may induce inflammation within the amniotic cavity and/or an increase in proinflammatory cytokines in fetal circulation. The aim was to investigate levels of IL-6 in maternal blood, umbilical cord blood, and amniotic fluid in pregnant women infected with SARS-CoV-2 at delivery. Methods: A single-center prospective observational case–control study of pregnant women diagnosed with SARS-CoV-2 infection at delivery was conducted. A total of 48 infected and 42 healthy women had IL-6 concentrations measured in their blood, amniotic fluid, and umbilical cord blood. Results: The concentrations of IL-6 in maternal blood and amniotic fluid were similar in the study and control groups, while umbilical cord blood concentrations were significantly higher in SARS-CoV-2-positive women. The umbilical cord blood IL-6 concentration was related to composite neonatal morbidity. Conclusions: Maternal SARS-CoV-2 infection in pregnant women at delivery increases umbilical cord blood IL-6 concentration. The correlation between maternal and umbilical blood concentrations indicates a possibility of passage of IL-6 through the placenta. Perinatal alterations resulting from maternal SARS-CoV-2 infection at delivery carry a risk of impacting the health of infants even in asymptomatic course of infection.
- Subjects
CORD blood; AMNIOTIC liquid; INTERLEUKIN-6; SARS-CoV-2; AMNIOTIC fluid embolism; PREGNANT women
- Publication
Journal of Clinical Medicine, 2023, Vol 12, Issue 17, p5672
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm12175672