We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Induction of Labor with Vaginal Dinoprostone (PGE 2) in Patients with a Previous Cesarean Section: Obstetric and Neonatal Outcomes.
- Authors
López-Jiménez, Nuria; García-Sánchez, Fiamma; Pailos, Rafael Hernández; Rodrigo-Álvaro, Valentin; Pascual-Pedreño, Ana; Moreno-Cid, María; Hernández-Martínez, Antonio; Molina-Alarcón, Milagros
- Abstract
Background: Vaginal dinoprostone (PGE2) is currently used as the prostaglandin of choice in many obstetric units. However, few studies have evaluated its safety, especially in women who previously had a cesarean section. Objective: To evaluate the efficacy and safety of PGE2 in pregnant women who are undergoing induction of labor (IOL), and who have had a previous cesarean section. Materials and Methods: A prospective observational study was conducted in La Mancha Centro Hospital in Alcázar de San Juan, Spain, from 1 February 2019 to 30 August 2020. Obstetric and neonatal outcomes, following IOL with PGE2, in 47 pregnant women who wanted a trial of labor after cesarean (TOLAC), and 377 pregnant women without a history of cesarean section, were analyzed. The outcomes were analyzed by bivariate and multivariate analyses using binary and multiple linear regression. Results: A total of 424 women were included in this study. The percentage of cesarean sections in the TOLAC group was 44.7% (21), compared with 31.6% (119) in the group without a history of cesarean section (adjusted odds ratio: 1.4; 95% CI: 0.68–2.86). In the multivariate analysis, no statistically significant differences were observed between both groups for obstetric and neonatal outcomes (p > 0.05). However, two uterine ruptures (4.3%) occurred in the group of patients with a history of cesarean section who underwent IOL with PGE2. Conclusions: The induction of labor with vaginal dinoprostone (PGE2), in patients with a previous history of cesarean section, was not associated with worse obstetric or neonatal outcomes compared with the group of patients without a history of cesarean section in our study sample. However, further research is needed regarding this IOL method, and it should be used with caution in this population group.
- Subjects
CASTILLA-La Mancha (Spain); CESAREAN section; INDUCED labor (Obstetrics); DINOPROSTONE; PREGNANT women; UTERINE rupture
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 22, p5221
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10225221