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- Title
Genetic Variants as Sudden-Death Risk Markers in Inherited Arrhythmogenic Syndromes: Personalized Genetic Interpretation.
- Authors
Campuzano, Oscar; Sarquella-Brugada, Georgia; Arbelo, Elena; Cesar, Sergi; Jordà, Paloma; Pérez-Serra, Alexandra; Toro, Rocío; Brugada, Josep; Brugada, Ramon
- Abstract
Inherited arrhythmogenic syndromes are the primary cause of unexpected lethal cardiac episodes in young people. It is possible that the first sign of the condition may be sudden death. Inherited arrhythmogenic syndromes are caused by genetic defects that may be analyzed using different technical approaches. A genetic alteration may be used as a marker of risk for families who carry the genetic alterations. Therefore, the early identification of the responsible genetic defect may help the adoption of preventive therapeutic measures focused on reducing the risk of lethal arrhythmias. Here, we describe the use of massive sequencing technologies and the interpretation of genetic analyses in inherited arrhythmogenic syndromes.
- Subjects
SUDDEN death; SYNDROMES; CARDIAC arrest; ARRHYTHMIA; BRUGADA syndrome
- Publication
Journal of Clinical Medicine, 2020, Vol 9, Issue 6, p1866
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm9061866