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- Title
Kardiyak Sendrom X Hastalarında CYP2J2 Polimorfizminin Belirlenmesi.
- Authors
Akal, Melissa Tatlıdil; Önal, Burak; Özen, Deniz; Demir, Bülent; Akkan, Ahmet Gökhan; Özyazgan, Sibel
- Abstract
Aim: Cardiac Syndrome X patient population is defined as typical angina with detected ischemia in non-invasive tests and normal epicardial coronary arteries in coronary angiography. The increase in CRP levels and other inflammatory markers in CSX patients indicates that the disease has an inflammatory pathogenesis. CYP2J2, a cytochrome P450 enzyme, is expressed in high amounts in the coronary artery endothelium, smooth muscle cells and cardiomyocytes. The main role of CYP2J2 is derivation of arachidonic acid into 4 different types of epoxyeicosatrieonic acids (EET), which are 5,6-, 8,9-, 11,12-14,15-. These EETs inhibit formation of the inflammatory response by decreasing endothelial expression of TNF-a induced VCAM-1 and reduce the adhesion of leukocytes to vascular endothelium by inhibiting NF-κB. CYP2J2 gene -76G>T polymorphism causes a decrease in expression of CYP2J2 and its metabolites. In this study, we aimed to investigate the relationship between CSX, in whose pathophysiology inflammation is thought to play a role and CYP2J2 gene -76G>T polymorphism, which is known to be involved in inflammatory response. Material and Method: We compared consecutive 125 CSX patients and 125 healthy individuals in terms of CYP2J2 gene -76G>T polymorphism. The genotyping of the polymorphism was applied by using real time-PCR method. Results: There was no statistically significant difference between the patients and the control when TT, GT and GG genotypes were analyzed (p>0,05). Conclusion: It is suggested that CYP2J2 -76G>T polymorphism does not play an important role in the pathogenesis of CSX.
- Subjects
VASCULAR cell adhesion molecule-1; VASCULAR endothelium; CORONARY arteries; CYTOCHROME P-450; ARACHIDONIC acid; GENETIC polymorphisms; CORONARY vasospasm; TISSUE adhesions
- Publication
Kafkas Journal of Medical Sciences / Kafkas Tıp Bilimleri Dergisi, 2019, Vol 9, Issue 2, p79
- ISSN
2146-2631
- Publication type
Article
- DOI
10.5505/kjms.2019.48264