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- Title
Imbalanced Th17/Treg in peripheral blood of adult patients with immunoglobulin A vasculitis nephritis.
- Authors
XUE XUE; QIANG LIU; WENCHENG XU; JUN YUAN; HUIMIN ZHOU; XINRONG ZOU; SIPING HAN; XIANGYAN MENG; XIAOQIN WANG
- Abstract
Introduction: Adult immunoglobulin A vasculitis nephritis (IgAVN) was observed to be more severe than the disease in children because it tended to result in a poor prognosis. The present study analyzed the Th17/Treg cell axis in peripheral blood of adult IgAVN patients, aiming to provide new immunological viewpoints for the pathogenesis of adult IgAVN. Material and methods: Th17 cell and Treg cell frequencies in peripheral blood of healthy subjects (n = 13) and adult IgAVN patients (n = 12) were analyzed by flow cytometry. Foxp3 mRNA in peripheral blood of healthy subjects and adult IgAVN patients was detected by RT-PCR. Interleukin (IL)-17 and IL-10 in peripheral blood serum of healthy subjects and adult IgAVN patients were examined by ELISA. Results: The percentages of CD4+ Th17+ cells in peripheral blood of healthy subjects and adult IgAVN patients were 2.65 ±1.55% and 4.37 ±1.68% respectively. The percentages of Treg cells in peripheral blood of healthy subjects and adult IgAVN patients were 6.44 ±2.90% and 3.91 ±1.94% respectively. The ratio of Th17/Treg in adult IgAVN patients was significantly higher than that of healthy subjects (p = 0.0030). Meanwhile, the Foxp3 mRNA expression of adult IgAVN patients was significantly lower than that of healthy subjects. There was a significant difference in the ratio of IL-17/IL-10 between healthy subjects and adult IgAVN patients (p < 0.0001). A significant correlation between red blood cell distribution width (RDW) and the ratio of Th17/Treg in adult IgAVN patients was observed in Spearman correlation analysis (r = 0.6970, p = 0.0145). Conclusions: Imbalanced Th17/Treg contributed to the complex pathogenesis of adult IgAVN.
- Subjects
ADULTS; REGULATORY T cells; ERYTHROCYTES; T helper cells; VASCULITIS; MUCOCUTANEOUS lymph node syndrome; NEPHRITIS
- Publication
Central European Journal of Immunology, 2021, Vol 46, Issue 2, p191
- ISSN
1426-3912
- Publication type
Article
- DOI
10.5114/ceji.2021.108176