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- Title
Association between cord blood IgE and genetic polymorphisms of interleukin-4, the β-subunit of the high-affinity receptor for IgE, lymphotoxin- α, and tumor Necrosis factor- α.
- Authors
Hui-Ju Wen; Ying-Chu Lin; Yung-Ling Lee; Yueliang Leon Guo
- Abstract
High cord blood immunoglobulin E (cbIgE) is known to be associated with increased risks of atopic diseases in childhood. The relationship between genetic polymorphisms and high cbIgE has not been well documented. A cross-sectional study was conducted to assess the association between cbIgE and genetic polymorphisms of interleukin (IL)-4 -590C/T, the β-subunit of the high-affinity receptor for IgE (Fc ℇRI- β) E237G, lymphotoxin (LT)- α NcoI alleles, and tumor necrosis factor (TNF)- α -308G/A. A total of 320 mother–neonate pairs were recruited from four maternity hospitals from different locations of Taiwan. Cord blood was obtained and assayed for cbIgE. Polymerase chain reaction followed by restriction fragment length polymorphism was used to assess the genotypes. Three hundred pairs of mothers and neonates were included in the final analysis. Infants with IL-4 -590 C allele were found to have higher risk of elevated cbIgE (≥0.35 IU/ml, 24.3%) (p = 0.004). After adjusting for gender, birth order, maternal age, and history of allergic disease in maternal and paternal families, odds ratios for CC and CT genotypes were 4.41 and 3.16 (95% confidence interval 0.78–22.67, and 1.66–6.13), respectively, using TT genotype as reference. The genotypes of Fc ℇRI- β, LT- α, and TNF- α were not associated with cbIgE before or after the adjustment. Our finding suggested a significant association of cbIgE with genetic polymorphism of IL-4 -590C/T, but not with the genotypes of Fc ℇRI- β, LT- α, and TNF- α.
- Subjects
INTERLEUKIN-4; IMMUNOGLOBULIN E; TUMOR necrosis factors; GENETIC polymorphisms; POLYMERASE chain reaction; ALLERGIES; CORD blood
- Publication
Pediatric Allergy & Immunology, 2006, Vol 17, Issue 7, p489
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/j.1399-3038.2006.00461.x