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- Title
Validation of a high performance liquid chromatography method for sunscreen determination in cosmetics.
- Authors
Dutra, E. A; Kedor-Hackmann, E. R. M; Santoro, M. I. R. M
- Abstract
The aim of this research was the development and validation of a high performance liquid chromatography (HPLC) method for the simultaneous and quantitative determination of benzophenone-3, octyl methoxycinnamate and octyl salicylate contained in sunscreen emulsions. The separation and quantitative determination was achieved using a LiChrospher® 100 RP-18 (5 µm) Merck column, a mobile phase constituted of methanol/water (85/15, v/v), a flow-rate of 1.0 mL min-1 and UV detection at 310 nm. The correlation coefficients and percentage of recovery for benzophenone-3, octyl methoxycinnamate and octyl salicylate were 0.9999 and 99.46%; 0.9995 and 98.85%; 0.9998 and 98.84%, respectively. The relative standard deviations (RSD) for commercial samples were between 0.50 and 0.70%.
- Subjects
CHROMATOGRAPHIC analysis; COSMETICS
- Publication
International Journal of Cosmetic Science, 2002, Vol 24, Issue 2, p97
- ISSN
0142-5463
- Publication type
Article
- DOI
10.1046/j.1467-2494.2002.00125.x