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- Title
Spontaneous production of B cell growth factors by SLE lymphocytes.
- Authors
Pelton, B. K.; Denman, A. M.
- Abstract
Systemic lupus erythematosus blood lymphocytes produce B cell growth factors (BCGF) spontaneously to an extent comparable with pokeweed mitogen-stimulated lymphocytes from normal donors. BCGF production by SLE lymphocytes is not increased by PWM and these cells are refractory to exogenous BCGF. Production requires B cells and irradiated T cells but not accessory cells. The properties of spontaneously synthesized BCGF differ in some respects from those induced by PWM. These findings suggest that the abnormal H cell proliferation characteristic of SLE may result, al least in part, from autostimulatory growth factors.
- Subjects
LYMPHOCYTES; LEUCOCYTES; SYSTEMIC lupus erythematosus; COLLAGEN diseases; AUTOIMMUNE diseases; SKIN diseases
- Publication
Clinical & Experimental Immunology, 1987, Vol 67, Issue 1, p159
- ISSN
0009-9104
- Publication type
Article