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- Title
Evaluation of alternative pathway and factor B haemolytic activities in patients with systemic lupus erythematosus: correlations with the alternative pathway regulatory proteins.
- Authors
Aguado, M. Teresa; Perrin, L. H.; Ramirez, R.; Miescher, P. A.; Lambert, P.-H.
- Abstract
The haemolytic activities of the complement alternative pathway and factor S were studied using a 51Cr-release assay in 77 sera from patients with systemic lupus erythematosus (SLE). These values were compared to those of several complement components and of the regulatory proteins β1H and C3b INA. There was a significant decrease in the alternative pathway activity, which correlated with a decrease in the haemolytic activity of factor B and with the activity of the classical pathway. There was a significant decrease in the level of one regulatory protein. βH. while the level of the other regulatory protein. C3b INA. was increased; however, there was a positive correlation between these two parameters. The results obtained suggest that the decreased activity of the alternative pathway observed in SLE reflects a consumption due to a triggering of the C3b amplification loop through the activation of the classical pathway. In one patient. an acquired deficiency of the capacity to activate the alternative pathway in the presence of inulin was observed.
- Subjects
SKIN diseases; SYSTEMIC lupus erythematosus; LUPUS erythematosus; AUTOIMMUNE diseases; VASCULAR diseases; BLOOD plasma
- Publication
Clinical & Experimental Immunology, 1980, Vol 42, Issue 3, p495
- ISSN
0009-9104
- Publication type
Article