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- Title
Histological and immunohistochemical study of the effect of experimentally induced hypothyroidism on the thyroid gland and bone of male albino rats.
- Authors
Elkalawy, Seham A. M.; Abo-Elnour, Rahma K.; El Deeb, Dalia F.; Yousry, Marwa M.
- Abstract
Hyperstimulation of follicular cells using a goitrogen [propylthiouracil (PTU)] caused thyroid dysfunctions that were associated with disturbances in adult bone turnover.This work was carried out to study the probable relationship between follicular and parafollicular cells in drug-induced hypothyroidism caused by PTU and consequently its effect on bone.The present work was carried out on 30 adult male albino rats divided into three groups. Group I was the control group; group II (the hypothyroid group) rats received PTU orally at a daily dose of 16.875 mg/rat of an average weight of 180 g for 4 weeks; group III was the recovery group. Thyroid glands were examined using histological and immunohistochemical techniques for calcitonin Ab-2. The midshaft of the femur bones of the studied groups was prepared and stained with H&E.In hypothyroid rats both follicular and C cells displayed signs of hyperactivity as the mean follicular cell height was significantly increased (P<0.05) compared with the control group. Moreover, the calcitonin immunoreactive cells showed a significant increase (P<0.05) in the mean values of their height and mean area% and number compared with the control group. These findings were reflected on bone sections in terms of a significant increase (P<0.05) in cortical bone thickness and a significant narrowing (P<0.05) of the Haversian canals when compared with the control group.It could be concluded that C cells are not exclusively involved in calcium regulation independent of follicular cell activity; however, these cells interact with the surrounding follicular cells, enabling more effective coordinated functions between the two endocrine populations. Moreover, experimentally induced hypothyroidism resulted in increased C-cell number, consequently decreasing bone resorption and increasing cortical bone thickness.
- Publication
Egyptian Journal of Histology, 2013, Vol 36, Issue 1, p92
- ISSN
1110-0559
- Publication type
Article
- DOI
10.1097/01.EHX.0000424169.63765.ac