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- Title
Recent patents in allergy and immunology: A quantitative real‐time polymerase chain reaction method for diagnosing asthma and asthma exacerbation.
- Authors
Lee, Pureun‐Haneul; Choi, SeonMuk; An, MinHyeok; Jang, An‐Soo
- Abstract
Background: Asthma is diagnosed based on a history of the characteristic symptoms and evidence of expiratory airflow limitation. However, asthma diagnosis using the existing tests is associated with a risk of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 spread. In this study, we developed a quantitative real‐time polymerase chain reaction (qRT‐PCR)‐based asthma diagnosis tool. Methods: We detected nectin‐4 in the plasma of patients with asthma using qRT‐PCR, explored the relationship of clinical variables. Results: quantitative real‐time polymerase chain reaction revealed that plasma nectin‐4 mRNA levels were higher in asthmatics than controls. These results correlated with lung function. Conclusions: Those results suggest that qRT‐PCR for nectin‐4 may aid asthma diagnosis and monitoring.
- Subjects
COVID-19; SARS-CoV-2; ASTHMA
- Publication
Clinical & Translational Allergy, 2022, Vol 12, Issue 4, p1
- ISSN
2045-7022
- Publication type
Article
- DOI
10.1002/clt2.12136