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- Title
Effects of Thyroid Hormones on Serum Levels of Adipokines as Studied in Patients with Differentiated Thyroid Carcinoma During Thyroxine Withdrawal.
- Authors
Botella-Carretero, José I.; Alvarez-Blasco, Francisco; Sancho, Jos; Escobar-Morreale, Héctor F.
- Abstract
Objective: Previous studies addressing the influence of thyroid hormones on serum levels of adipokines yielded conflicting results. We aimed to study the impact of short-term overt hypothyroidism on serum leptin, resistin, and adiponectin levels in an in vivo human model. Design: Twenty-two women with differentiated thyroid carcinoma were studied the last day of their thyroxine-suppressive treatment, 4-7 days after withdrawal, and the day before whole-body scanning. Evaluations included serum thyroid hormone, leptin, resistin, and adiponectin concentrations, fasting glucose and insulin, lipid profiles, body temperature, body mass index, and total body fat mass. Main outcomes: Thyroid function changed from subclinical or mild hyperthyroidism to normal free thyroxine and triiodothyronine levels, ending in overt hypothyroidism. Thyroxine withdrawal resulted in an increase in serum resistin ( p = 0.007) and leptin ( p = 0.006) concentrations, whereas adiponectin levels remain unchanged. A significant decrease in body temperature during thyroxine withdrawal was paralleled by a decrease in fasting glucose ( p = 0.006) and insulin resistance ( p = 0.033), which occurred despite an increase in estimated total body fat mass. Conclusion: Thyroid hormones are important regulators of energy balance and intermediate metabolism, influencing the serum concentrations of leptin and resistin.
- Publication
Thyroid, 2006, Vol 16, Issue 4, p397
- ISSN
1050-7256
- Publication type
Article
- DOI
10.1089/thy.2006.16.397