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- Title
Shedding Lights on Crude Venom from Solitary Foraging Predatory Ant Ectatomma opaciventre : Initial Toxinological Investigation.
- Authors
Correia, Lucas Ian Veloso; Azevedo, Fernanda Van Petten de Vasconcelos; Amorim, Fernanda Gobbi; Cirilo Gimenes, Sarah Natalie; Polloni, Lorena; Zoia, Mariana Alves Pereira; Costa, Mônica Soares; Rodrigues, Jéssica Peixoto; Yoneyama, Kelly A. Geraldo; Santos, Jean Carlos; Arantes, Eliane Candiani; Rodrigues, Veridiana de Melo; Goulart, Luiz Ricardo; Rodrigues, Renata Santos
- Abstract
Some species of primitive predatory ants, despite living in a colony, exercise their hunting collection strategy individually; their venom is painful, paralyzing, digestive, and lethal for their prey, yet the toxins responsible for these effects are poorly known. Ectatomma opaciventre is a previously unrecorded solitary hunting ant from the Brazilian Cerrado. To overcome this hindrance, the present study performed the in vitro enzymatic, biochemical, and biological activities of E. opaciventre to better understand the properties of this venom. Its venom showed several proteins with masses ranging from 1–116 kDa, highlighting the complexity of this venom. Compounds with high enzymatic activity were described, elucidating different enzyme classes present in the venom, with the presence of the first L-amino acid oxidase in Hymenoptera venoms being reported. Its crude venom contributes to a state of blood incoagulability, acting on primary hemostasis, inhibiting collagen-induced platelet aggregation, and operating on the fibrinolysis of loose red clots. Furthermore, the E. opaciventre venom preferentially induced cytotoxic effects on lung cancer cell lines and three different species of Leishmania. These data shed a comprehensive portrait of enzymatic components, biochemical and biological effects in vitro, opening perspectives for bio-pharmacological application of E. opaciventre venom molecules.
- Subjects
SNAKE venom; VENOM; BLOOD platelet aggregation; ANTS; LUNG cancer; CELL lines; TOXINS; BLOOD platelets
- Publication
Toxins, 2022, Vol 14, Issue 1, p37
- ISSN
2072-6651
- Publication type
Article
- DOI
10.3390/toxins14010037