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- Title
Inibição de enzimas digestivas por pellets de lúpulo (Humulus lupulus L.).
- Authors
Marques, Tamara Rezende; Silva Pereira, Luciana Lopes; Simão, Anderson Assaid; de Oliveira Ramos, Vinicius; Braga, Mariana Aparecida; Corrêa, Angelita Duarte; dos Santos, Custodio Donizete
- Abstract
(Inhibition of digestive enzymes by pellets of hop (Humulus lupulus L.)). The use of medicinal plants represents a wide field of research in the search for new therapeutic sources for the treatment of obesity, among other diseases. The objective of this study was to evaluate the inhibitory potential of the aqueous hop extract (in pellet form) on the digestive enzymes ɑ-amylase, ɑ-glucosidase, lipase and trypsin. An aqueous hop extract (in pellet form) was prepared in the 1:20 ratio (w/v) and used as an inhibitor in enzyme assays, which were performed in the absence and presence of simulated gastric fluid, in order to simulate the digestive process in the stomach in vitro. The effect of temperature on the activity of the inhibitors was also evaluated. In the absence of simulated gastric fluid, there was inhibition of enzymes ɑ-amylase (80.91 ± 1.16%), ɑ-glucosidase (40.96 ± 3.57%) and trypsin (67.48 ± 3.69%), whereas in the presence of simulated gastric fluid the inhibitory capacity of the extract disappeared for ɑ-amylase, had a slight increase for ɑ-glucosidase (44.25 ± 2.81%) and a significant increase for trypsin (89.01 ± 1.45%). Heat treatment did not alter the inhibitory capacity of the extract. We concluded that the aqueous hop extract has a potential use in the treatment of obesity. However, a more detailed study is still necessary for better understanding its mechanisms of action, which would thus enable future applications in the treatment of this pathology or for several therapeutic purposes.
- Subjects
BRAZIL; HOPS; DIGESTIVE enzymes; ENZYME inhibitors; OBESITY treatment; MEDICINAL plants; MEDICAL research; THERAPEUTICS
- Publication
Revista Brasileira de Biociencias, 2014, Vol 12, Issue 4, p183
- ISSN
1679-2343
- Publication type
Article