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- Title
Significance of <sup>11</sup>C-PIB PET/CT in cardiac amyloidosis compared with <sup>99m</sup>Tc-aprotinin scintigraphy: A pilot study.
- Authors
Minamimoto, Ryogo; Awaya, Toru; Iwama, Kentaro; Hotta, Masatoshi; Nakajima, Kazuhiko; Hirai, Risen; Okazaki, Osamu; Hiroi, Yukio
- Abstract
<bold>Background: </bold>This study was to investigate the significance of 11C-Pittsburgh B (PIB) PET/CT in patients with suspected cardiac amyloidosis compared with 99mTc-aprotinin scintigraphy.<bold>Methods: </bold>Thirteen consecutive patients with suspected cardiac amyloidosis were considered for enrolment in this prospective pilot study. Participants were scheduled to undergo a series of 11C-PIB PET/CT and 99mTc-aprotinin within a 2-month period. Finally, we evaluated nine cases who underwent both imaging modalities, and compared imaging results with clinical and pathological results and prognosis.<bold>Results: </bold>Six of the 9 patients who underwent both imaging modalities were diagnosed with amyloidosis, of whom 3 patients were diagnosed with cardiac amyloidosis from endomyocardial biopsy. These 3 patients with positive 11C-PIB uptake at the left ventricle wall showed worsening of cardiac function progressing in the short term or death caused by acute exacerbation of chronic heart failure. Six of 8 patients with positive uptake on 99mTc-aprotinin presented with amyloid deposition in the left ventricle wall, but symptoms remained stable if results of 11C-PIB were not positive.<bold>Conclusion: </bold>In a small sample of subjects, the present study showed that 11C-PIB accumulation in myocardium indicated cardiac amyloidosis with poor prognosis. Uptake of 11C-PIB may be related to progressive amyloid deposition to the heart and can predict patient prognosis.
- Subjects
PITTSBURGH (Pa.); RADIONUCLIDE imaging; CARDIAC amyloidosis; PILOT projects; HEART failure; CAUSES of death; CARDIAC patients; RESEARCH; AMYLOIDOSIS; PREDICTIVE tests; RESEARCH methodology; ORGANIC compounds; RADIOISOTOPES; MEDICAL cooperation; EVALUATION research; AMINES; COMPARATIVE studies; APROTININ; THIAZOLES; HEART diseases; LONGITUDINAL method
- Publication
Journal of Nuclear Cardiology, 2020, Vol 27, Issue 1, p202
- ISSN
1071-3581
- Publication type
journal article
- DOI
10.1007/s12350-018-1260-5