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- Title
Abnormalities of myocardial perfusion and glucose metabolism in patients with isolated left ventricular non-compaction.
- Authors
Gao, Xiao-Jin; Li, Yan; Kang, Lian-Ming; Zhang, Jian; Lu, Min-Jie; Wan, Jun-Yi; Luo, Xiao-Liang; He, Zuo-Xiang; Zhao, Shi-Hua; Yang, Min-Fu; Yang, Yue-Jin
- Abstract
Background: The prevalence of myocardial perfusion and glucose metabolic abnormalities and their significance in patients with isolated left ventricular non-compaction (ILVNC) have not been well investigated. Methods: Seventeen ILVNC patients who underwent cardiac magnetic resonance (CMR) and Tc-sestamibi SPECT/fluorine-18 deoxyglucose (F-FDG) PET imaging were included. Left ventricular non-compaction, regional wall motion abnormalities, left ventricular ejection fraction (LVEF), and delayed enhancement (DE) were estimated using CMR. Myocardial perfusion and metabolism were evaluated with SPECT/PET. Results: Ninety-five (32.9%) segments were considered non-compacted. DE was present in 52 (18.0%) segments and 10 (58.8%) patients. The rate of occurrence of DE was significantly higher in compacted segments than in non-compacted segments (22.7% vs 8.4%, P = .003). Myocardial perfusion abnormalities were present in 92 (31.8%) segments, of which 66 were perfusion/metabolism match and 26 were perfusion/metabolism mismatch. The rate of occurrence of perfusion abnormality was similar between compacted and non-compacted segments (32.0% vs 31.6%, P = .948), but it was significantly higher in segments with DE than in those without DE (51.9% vs 27.4%, P = .001). None of the imaging features alone (non-compaction, DE, perfusion abnormalities, match or mismatch) showed significant correlations with LVEF (all P > .05). Conclusion: In the current study, myocardial perfusion/metabolism mismatch and match were observed in both non-compacted and compacted myocardium in ILVNC patients. Further research is warranted to determine their pathologic and clinical significance.
- Subjects
MYOCARDIAL perfusion imaging; GLUCOSE metabolism; MAGNETIC resonance imaging; MYOCARDIUM; DIAGNOSTIC imaging; HEART metabolism; POSITRON emission tomography
- Publication
Journal of Nuclear Cardiology, 2014, Vol 21, Issue 3, p633
- ISSN
1071-3581
- Publication type
Article
- DOI
10.1007/s12350-014-9890-8