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- Title
Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: results from a follow-up study.
- Authors
Phelan, C M; Iqbal, J; Lynch, H T; Lubinski, J; Gronwald, J; Moller, P; Ghadirian, P; Foulkes, W D; Armel, S; Eisen, A; Neuhausen, S L; Senter, L; Singer, C F; Ainsworth, P; Kim-Sing, C; Tung, N; Llacuachaqui, M; Chornokur, G; Ping, S; Narod, S A
- Abstract
Background:The BRCA1 and BRCA2 genes confer increased susceptibility to breast and ovarian cancer and to a spectrum of other cancers. There is controversy regarding the risk of colorectal cancer conferred by germline mutations in these two genes.Methods:We followed 7015 women with a BRCA mutation for new cases of colorectal cancer. Incidence rates in carriers were compared with population-specific incidence rates, and standardised incidence ratios (SIRs) were estimated. The expected numbers of cancers were computed by multiplying person-years at risk by the appropriate age-, sex- and country-specific incidence rates from the five countries.Results:Twenty-one incident colorectal cancer cases were observed among all mutation carriers, compared with 23.6 cases expected. The SIR for BRCA1 carriers was 0.92 (95% confidence interval (CI), 0.54-1.40, P=0.7) and for BRCA2 carriers was 0.82 (95% CI, 0.30-1.81, P=0.7). The SIR for colon cancer was 3.81 (95% CI 1.77-7.23) for women below the age of 50 years (both genes combined) and was 0.60 (95% CI 0.33-1.00) for women aged 50 years and above.Conclusion:The risk of colorectal cancer is increased in female carriers of BRCA1 mutations below the age of 50 years but not in women with BRCA2 mutations or in older women.
- Subjects
GENETICS of colon cancer; GENETIC mutation; FOLLOW-up studies (Medicine); DISEASE susceptibility; COLON cancer risk factors; GERM cells
- Publication
British Journal of Cancer, 2014, Vol 110, Issue 2, p530
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/bjc.2013.741