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- Title
Evaluation of the Safety and Immunogenicity of the RTS,S/ASO1<sub>E</sub> Malaria Candidate Vaccine When Integrated in the Expanded Program of Immunization.
- Authors
Agnandji, Selidji T.; Asante, Kwaku Poku; Lyimo, John; Vekemans, Johan; Souianoudjingar, Solange S.; Owusu, Ruth; Shomari, Mwanajaa; Leach, Amanda; Fernandes, Jose; Dosoo, David; Chikawe, Maria; lssifou, Saadou; Osei-Kwakye, Kingsley; Lievens, Marc; Paricek, Maria; Apanga, Stephen; Mwangoka, Grace; Okissi, Blaise; Kwara, Evans; Minja, Rose
- Abstract
Background. The RTS,S/ASO1E malaria candidate vaccine is being developed for immunization of African infants through the Expanded Program of Immunization (EPI). Methods. This phase 2, randomized, open, controlled trial conducted in Ghana, Tanzania, and Gabon evaluated the safety and immunogenicity of RTS,SIASO1E when coadministered with EPI vaccines. Five hundred eleven infants were randomized to receive RTS,S/ASO1E at 0, 1, and 2 months (in 3 doses with diphtheria, tetanus, and wholecell pertussis conjugate [DTPw]; hepatitis B [HepBJ; Haemophilus influenzae type b [Hib]; and oral polio vaccine IOPV]), RTS,S/ASO1 at 0, 1, and 7 months (2 doses with DTPwHepB/Hib+OPV and 1 dose with measles and yellow fever), or EPI vaccines only. Results. The occurrences of serious adverse events were balanced across groups; none were vaccine-related. One child from the control group died. Mild to moderate fever and diaper dermatitis occurred more frequently in the RTS,SIASO1E coadministration groups. RTS,S/ASOIE generated high anti-circumsporozoite protein and antihepatitis B surface antigen antibody levels. Regarding EPI vaccine responses upon coadministration when considering both immunization schedules, despite a tendency toward lower geometric mean titers to some EPI antigens, predefined noninferiority criteria were met for all EPI antigens except for polio 3 when EPI vaccines were given with RTS,S/ASO1E at 0, 1, and 2 months. However, when antibody levels at screening were taken into account, the rates of response to polio 3 antigens were comparable between groups. Conclusion. RTS,S/ASO1E integrated in the EPI showed a favorable safety and immunogenicity evaluation. Trial registration. ClinicalTrials.gov identifier: NCT00436007. GlaxoSmithKline study ID number: 106369 (Malaria-050).
- Subjects
MALARIA vaccines; IMMUNIZATION of infants; INFANT health; HAEMOPHILUS influenzae; POLIOMYELITIS vaccines; ANTIGENS; VACCINATION
- Publication
Journal of Infectious Diseases, 2010, Vol 202, Issue 7, p1076
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/656190