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- Title
Antibody Persistence after 2-Dose Priming and Booster Response to a Third Dose of an Inactivated, Adjuvanted, Whole-Virion H5N1 Vaccine.
- Authors
Jiang-Tao Lin; Chang-Gui Li; Xu Wang; Nan Su; Yan Liu; Yuan-Zheng Qiu; Meng Yang; Jiang-Ting Chen; Han-Hua Fang; Xiao-Ping Dong; Wei-Dong Yin; Zi-Jian Feng
- Abstract
An inactivated, alum-adjuvanted, whole-virion H5N1 vaccine had been evaluated previously. Hemagglutination inhibition (HI) assays showed that the antibody levels declined significantly, with 4.8%-20.8% and 0%-18.8% of participants retaining seroprotection (HI titer ⩾ 1:40) 6 and 12 months after the second dose, respectively. A third dose of the same vaccine given 12 months after the second dose significantly boosted immune responses. Thirty days after the third dose in the 1.25-, 2.5-, 5-, and 10-μg dose groups, 29.4%, 31.3%, 78.6%, and 90.0% of participants had HI titers ⩾1:40,and 52.9%, 81.2%, 92.9%, and 100% of participants had microneutralization titers ⩾1:40, respectively. Both the 5-μg and 10-μg doses met European Union criteria. (ClinicalTrials.gov identifier: NCT00660257.)
- Subjects
VACCINATION; PREVENTIVE medicine; BLOOD agglutination; MEDICAL research; IMMUNE response; IMMUNOGLOBULINS; DRUG efficacy
- Publication
Journal of Infectious Diseases, 2009, Vol 199, Issue 2, p184
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/595832