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- Title
Altered Transcriptional Activity of Human Endogenous Retroviruses in Neuroepithelial Cells after Infection with Toxoplasma gondii.
- Authors
Frank, Oliver; Jones-Brando, Lorraine; Leib-Mösch, Christine; Yolken, Robert; Seifarth, Wolfgang
- Abstract
Human endogenous retroviruses (HERVs) arose in antiquity from stable integration into the human genome. The mechanism for activation of HERVs has not been fully elucidated. Toxoplasmosis, caused by Toxoplasma gondii, is a medically important parasitic infection with worldwide distribution. To search for a tentative link between toxoplasmosis and HERV activation, HERV expression profiles of human neuroepithelial SK-N-MC cells infected with T. gondii were analyzed. Increased transcriptional activity of class I, II, and III HERV elements was observed in infected cells, suggesting that T. gondii can influence the transcription of HERVs in neuronal cells.
- Subjects
RETROVIRUS genetics; HUMAN genome; ONCOGENIC viruses; TOXOPLASMA gondii; HUMAN gene mapping; GENE mapping; GENETIC research
- Publication
Journal of Infectious Diseases, 2006, Vol 194, Issue 10, p1447
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/508496