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- Title
Clearance of Circulating Epstein-Barr Virus DNA in Children with Acute Malaria after Antimalaria Treatment.
- Authors
Donati, Daria; Espmark, Eva; Kironde, Fred; Mbidde, Edward Katongole; Kamya, Moses; Lundkvist, Åke; Wahlgren, Mats; Bejarano, Maria Teresa; Falk, Kerstin I.
- Abstract
Children living in malaria-endemic regions have a high incidence of Burkitt lymphoma (BL), the etiology of which involves Plasmodium falciparum malaria and Epstein-Barr virus (EBV) infections. In the present study, we compared EBV DNA loads in plasma and saliva samples from Ugandan children with acute malaria (M+) at the time of diagnosis and 14 days after antimalaria treatment, children without malaria (M-), and children with BL. EBV DNA was detected, by real-time polymerase chain reaction, in 31% of the plasma and in 79% of the saliva samples from children in the M+ group. Antimalaria treatment led to clearance of plasma viral load in 85% of the cases but did not affect the levels in saliva. There was a significant difference in plasma EBV loads across the groups. The lowest levels were detected in samples from the M- group, increased levels were detected in samples from the M+ group, and levels reached the highest values in samples from children with BL. The same trend was evident in the frequency and levels of anti-BZLF1 antibodies, which is indicative of viral reactivation. In the M+ group, the positive plasma samples clustered around 7–9 years of age, the peak incidence of BL. The clearance of circulating EBV after antimalaria treatment suggests a direct relationship between active malaria infection and viral reactivation.
- Subjects
EPSTEIN-Barr virus; HERPESVIRUSES; ONCOGENIC DNA viruses; SEXUALLY transmitted diseases; COMMUNICABLE diseases; PLASMODIUM falciparum; MALARIA
- Publication
Journal of Infectious Diseases, 2006, Vol 193, Issue 7, p971
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/500839