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- Title
Immunological Response to Highly Active Antiretroviral Therapy in Children with Clinically Stable HIV-1 Infection.
- Authors
Rosenblatt, Howard M.; Stanley, Kenneth E.; Song, Lin Y.; Johnson, George M.; Wiznia, Andrew A.; Nacliman, Sharon A.; Krogstad, Paul A.
- Abstract
We studied changes in 60 immunological parameters after the administration of highly active antiretroviral therapy (HAART) in 192 clinically stable antiretroviral drug-experienced HIV-1-infected children 4 months- 17 years old. The studied immunological parameters included standard lymphocyte subsets and lymphocyte surface markers of maturation and activation. The most significant changes during the 48-week study period were seen for CD8+, CD8+CD62L+CD45RA+, CD8+CD38+HLA-DR+, and CD4+ T cell percentages (for P<.0001 all parameters). These changes suggest that significant decreases in the expression of activation markers and increases in the expression of naive markers in the CD8+ T cell population may be related to better virologic control in these HIV-1-infected children, who had relatively stable immune function at the initiation of HAART. At week 44 of HAART, the major immunological parameters in these HIV-1-infected children moved from baseline values to about halfway to two-thirds of the way toward the values in healthy, uninfected children.
- Subjects
HIV infections; JUVENILE diseases; ANTIRETROVIRAL agents; T cells; IMMUNOLOGY; LENTIVIRUS diseases
- Publication
Journal of Infectious Diseases, 2005, Vol 192, Issue 3, p445
- ISSN
0022-1899
- Publication type
Article