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- Title
CD130 rather than CD126 expression is associated with disease activity in multiple myeloma.
- Authors
Barillé, Sophie; Thabard, Wilfrid; Robillard, Nelly; Moreau, Philippe; Pineau, Danielle; Harousseau, Jean-Luc; Bataille, Régis; Amiot, Martine
- Abstract
We analysed the expression of both components of IL-6R, CD126 the ligand binding protein and CD130 the signal transducing protein, on plasma cells from MGUS and multiple myeloma (MM) cases using flow cytometry. CD126 was detectable in 50% of either MGUS or MM patients without any change of expression during disease progression. In contrast, CD130 expression was up-regulated during tumoural expansion (43% of MM patients at diagnosis versus 88% at relapse). Finally, combining CD126 and CD130 expression we found a significant increase of the percentage of CD126+ CD130+ patients at relapse, underlying the crucial role of IL-6 response in the late stage of MM.
- Subjects
CD antigens; MULTIPLE myeloma; INTERLEUKIN-6; FLOW cytometry
- Publication
British Journal of Haematology, 1999, Vol 106, Issue 2, p532
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.1999.01563.x