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- Title
IgG subclass antibodies against <em>Parietaria Judaica</em> in normal and allergic subjects.
- Authors
Palumbo, S.; Di Felice, G.; Mari, A.; Bonini, S.; Bruno, G.; Tinghino, R.; Afferni, C.; Sallusto, F.; Pini, C.
- Abstract
IgG antibody response to the inhalant allergen <em>Parietaria judaica</em> (Pj) and IgG subclass distribution were studied in 82 normal subjects, divided into three groups according to age (0-1, 1-20, and 20-60 years) and in 32 allergic subjects aged 20-60 years. Both normal and allergic subjects showed an IgG response, and all had IgG 1 antibodies specific for PjE. Serum IgG2, IgG3, and IgG4 against PjE were detectable in 36%, 46%, and 22% of normal subjects, and in 58%, 31%, and 65% of allergic subjects, respectively. A significant difference in class distribution between allergic and age-matched normal subjects was found only for IgG4 antibodies against PjE (65% and 17%; <em>P</em> < 0.01). The ELISA results were also analyzed quantitatively, taking into account the relative proportion of specific antibodies. Thus, in normal subjects IgG 1 antibodies showed a decreasing trend as the age rose, while no differences according to the age of the subject were found for IgG2 and IgG4. When data from allergic subjects (20-60 years) and the age-matched normal group were compared, they were different for the relative percentage of IgG2 only, showing for this a significantly lower value (<em>P</em> < 0.001). The present data indicate that normal and allergic subjects show differences in the IgG iso type distribution depending on their sensitivity and duration of allergen exposure.
- Subjects
IMMUNOGLOBULINS; ALLERGENS; GLOBULINS; PLASMA cells; BLOOD proteins; ANTIGENS
- Publication
Allergy, 1994, Vol 49, Issue 4, p222
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/j.1398-9995.1994.tb02653.x