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- Title
Progression of myeloproliferative neoplasm with BCR::JAK2 fusion to acute leukemia of ambiguous lineage.
- Authors
Suárez, Edwin Uriel; Piris, Miguel Ángel; Rodríguez-Pinilla, Socorro María; García, Juan F.; López-Lorenzo, José Luis; Cornago-Navascués, Javier; Salgado-Sánchez, Rocío; Castaño-Bonilla, Tamara; Mata-Serna, Raquel; Alonso-Domínguez, Juan M.; Llamas, Pilar
- Abstract
This letter, published in the Annals of Hematology, describes the case of a 58-year-old man who was initially diagnosed with myeloproliferative neoplasm (MPN) with a BCR::JAK2 fusion. The patient was treated with ruxolitinib, but later developed acute leukemia of ambiguous lineage (ALAL). Despite treatment with intensive chemotherapy, the patient's condition worsened, and they ultimately underwent an allogeneic hematopoietic stem cell transplantation (allo-HSCT). Unfortunately, the patient passed away due to complications. The letter highlights the rarity of the BCR::JAK2 fusion in MPN and the challenges in managing ALAL. The authors emphasize the need for further research and improved treatment options for post-MPN acute leukemia.
- Subjects
MYELOPROLIFERATIVE neoplasms; ACUTE leukemia; MYELOFIBROSIS; MAST cell disease; EXTRAMEDULLARY diseases; BLOOD diseases; BLOOD cell count
- Publication
Annals of Hematology, 2024, Vol 103, Issue 5, p1797
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-024-05647-6