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- Title
Association between systemic antibiotic and corticosteroid use for chronic rhinosinusitis and quality of life.
- Authors
Yamasaki, Alisa; Hoehle, Lloyd P.; Phillips, Katie M.; Feng, Allen L.; Campbell, Adam P.; Caradonna, David S.; Gray, Stacey T.; Sedaghat, Ahmad R.
- Abstract
<bold>Objective: </bold>We sought to establish the significance of querying chronic rhinosinusitis (CRS) patients about their past CRS-related oral antibiotic and corticosteroid usage by determining the association between these metrics and patients' quality of life (QoL).<bold>Study Design: </bold>Cross-sectional study.<bold>Methods: </bold>A total of 157 patients with CRS were prospectively recruited. CRS-specific QoL was measured using the 22-item Sinonasal Outcome Test (SNOT-22). General health-related QoL was measured using the EuroQoL five-dimensional questionnaire visual analog scale. Associations were sought between these measures of QoL and frequency of CRS-related oral antibiotic and corticosteroid usage reported by the participants in the prior 3 and 12 months.<bold>Results: </bold>More frequent antibiotic and corticosteroid use was significantly associated with worse CRS-specific and general health-related QoL, whether querying medication use over the prior 3 months or over the prior 12 months (P < 0.001 in all cases). The effect size of CRS-related antibiotic use during the prior 3 months on CRS-specific QoL (SNOT-22 score) was significantly greater than for use during the prior 12 months. However, there was no other statistically significant difference in effect size for association between QoL and CRS-related antibiotic or corticosteroid use in the prior 3 months versus prior 12 months. These results were independent of the presence or absence of polyps.<bold>Conclusion: </bold>More frequent past CRS-related oral antibiotic and corticosteroid use, regardless of time period queried (3 months or 12 months) is associated with significant decrease in CRS-specific and general health-related QoL. CRS-related systemic medication use is an important indicator of CRS patients' QOL that easily can be queried and utilized in both clinical and research settings.<bold>Level Of Evidence: </bold>2c. Laryngoscope, 128:37-42, 2018.
- Subjects
SINUSITIS; PHYSIOLOGICAL effects of antibiotics; PHYSIOLOGICAL effects of adrenocortical hormones; QUALITY of life; HORMONE therapy; CORTICOSTEROIDS; ANTIBIOTICS; NASAL polyps; PATIENTS; CHRONIC diseases; LONGITUDINAL method; ORAL drug administration; RHINITIS; CROSS-sectional method
- Publication
Laryngoscope, 2018, Vol 128, Issue 1, p37
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1002/lary.26778