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- Title
Effects ofl-tetrahydropalmatine on locomotor sensitization to oxycodonein mice.
- Authors
Yan-Li Liu; Jian-Hui Liang; Ling-Di Yan; Rui-Bin Su; Chun-Fu Wu; Ze-Hui Gong
- Abstract
Recent studies have shown that l-tetrahydropalmatine (l-THP), an active component ofCorydolis yanhusuo, can inhibit the development of the conditional place preference induced by opioid receptor agonists, but the effects oflTHP on locomotor sensitivity induced by opioid receptor agonists have not beendocumented. In the present study, the effects ofl-THP on locomotor sensitization to oxycodone, which is an opioid receptor agonist, were studied.Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization. In order to study the effects ofl-THP on locomotor sensitization induced by oxycodone,l-THP was administered at doses of 6.25, 12.5, and 18.75 mg/kg, 40 min prior to treatment of oxycodone.l-THPper sedid not affect the locomotor activity at the doses of 6.25, 12.5, and 18.75 mg/kg, but could antagonize the hyperactivity induced by oxycodone (5 mg/kg). Co-administration ofl-THP (18.75 mg/kg), 40 min prior to oxycodone, could inhibit the development of sensitization to oxycodone. In addition,l-THP (6.25, 12.5, and 18.75 mg/kg, ig) dose-dependently prevented the expression of oxycodone sensitization.These results suggested thatl-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization.
- Subjects
OPIOID receptors; DRUG receptors; CELL receptors; OXYCODONE; ANALGESICS
- Publication
Acta Pharmacologica Sinica, 2005, Vol 26, Issue 5, p533
- ISSN
1671-4083
- Publication type
Article
- DOI
10.1111/j.1745-7254.2005.00101.x