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- Title
Bioinformatic analysis of imidazopyridine-hydrazones as a possible alternative for the treatment of Influenza a virus.
- Authors
Ramírez-Sandoval, M. en C. Cristoper; Campos-Aldrete, María Elena
- Abstract
The Influenza virus has been of relevance in public health history, with great socioeconomic impact. Despite having the drugs Oseltamivir and Zanamivir for its treatment, it is not enough for its control, due to the limited access to vaccination and the constant evolutionary process of the virus, so it is of great importance to develop new therapeutic alternatives for its treatment. The present work focuses the study of molecular coupling of 2-Aryl-3-((2-(pyridin-2-yl)hydrazone) methyl)imidazo[1,2-a]pyridines and 3-R-2-((2-(pyridin-2-al)hydrazone)methyl) imidazo[1,2-a]pyridines which according to the site of binding to the protein domain of the compounds under study and the reference drug is established that the imidazo[1,2-a]pyridine derivatives have the same mode of action as the reference drug (Oseltamivir) showing greater affinity. Although the series of molecules extrapolated to the coordinates of the Osetamivir binding site will not be able to completely mimic the mechanism of action of the reference drug as a neuraminidase blocker, they will possibly follow a similar signaling route, and therefore a mechanism of similar action. The neuraminidase inhibition constant obtained for imidazopyridine derivatives was better (45-993 μM), compared to the reference drug Oseltamivir (1 730 μM). This concludes that by possessing a better inhibition constant and an established recognition topology, in addition to a mechanism of action to follow, this series of molecules are potentially functional and very promising as antiviral molecules.
- Publication
Veterinaria México OA, 2024, Vol 11, p85
- ISSN
2448-6760
- Publication type
Article
- DOI
10.22201/fmvz.24486760e.2024.1305