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- Title
Changes In The Cytokine Profile Of HIV/HCV Coinfected Patients Treated With Direct-Acting Antivirals.
- Authors
Garcia Martin1, Misael Osmar; Teran, Lourdes Pedroza; Ahumada Topete1, Víctor Hugo; Castillejos López, Manuel de Jesús; Sevilla Gutiérrez, Karina Danae; Teran, Gustavo Reyes; del Río Estrada, Perla Mariana; Ortega, Andrea Cárdenas; Ríos, Santiago Ávila; Isidro, Elvira Piten; Días Rivera, Dafné Eugenia; García, Edgar Luna
- Abstract
We evaluate the behavior of cytokines in HIV/HCV coinfected patients treated with direct acting antivirals (DAAs). Through a prospective study in patients > 18 years old HIV/HCV coinfected carriers treated with DAAS for 12 weeks. A baseline sample (prior to treatment) and 12 weeks post-treatment were taken. For the statistical analysis: descriptive (median and interquartile ranges for quantitative variables, frequencies, and percentages for qualitative variables). The comparison of cytokines was done using the Wilcoxon test. 27 patients were included vih years (SD 10.56), 96.3 % (26) were men, the most frequent genotype of HVC was 1A with 55.6 % (15), the DAAS received was: 14 (51.9 %) Sofosbuvir/Ledipasvir and 13 (48.1 %) Sofosbuvir/Velpatasvir, 100 % achieved sustained viral response. A cytokine profile (pg/ml) was analyzed obtaining the following significant results: sCD163: 48.8 (27.1-68) vs 32.1 (19.3-57.6) [P = 0.001], IL-12: 98.31 (78-165.9) vs 85 (55-162.7) [P = 0.039], RANTES: 716 (248.3-1151.5) vs 853.6 (389.6-3425.5) [P = 0.046], IL-15: 147.3 ( 43.1-560.5) vs 253.3 (74.1-627.97) [P = 0.035], IP-10: 89.3 (57.8-222.46) vs 26 (16.3-43.9) [P = 0.000], MIG: 131.4 (73.1-321.7) vs 99.6 (52.8-130.9) [P = 0.030]. With these results we can conclude the treatment with DAAS decreases the inflammatory and profibrotic response in HIV/HCV coinfected patients with sustained viral response.
- Subjects
CYTOKINES; HIV-positive persons; HEPATITIS C
- Publication
Veterinaria México OA, 2024, Vol 11, p37
- ISSN
2448-6760
- Publication type
Abstract
- DOI
10.22201/fmvz.24486760e.2024.1305