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- Title
OP04.01: Chromosomal aberrations in fetuses with isolated muscular ventricular septum defects: a retrospective study and meta‐analysis.
- Authors
Vedel, C.; Ekelund, C.K.; Hjortshøj, T.D.; Joergensen, F.S.; Zingenberg, H.J.; Roslev, A.; Petersen, O.B.
- Abstract
This article, titled "Chromosomal aberrations in fetuses with isolated muscular ventricular septum defects: a retrospective study and meta-analysis," investigates the association between prenatally detected isolated muscular ventricular septum defects (mVSD) and chromosomal aberrations. The study consists of a retrospective study from the Greater Copenhagen Region of Denmark and a meta-analysis. The retrospective study included pregnancies between January 1, 2015, and August 31, 2023, and found a prevalence of genetic aberrations of 1.1% in fetuses with isolated mVSD. The meta-analysis, which included data from the Capital Region of Denmark, indicated a prevalence of genetic aberrations of 0.51% in fetuses with isolated mVSD. These findings suggest that the prevalence of genetic aberrations in fetuses with isolated mVSD is comparable to low-risk pregnancies without malformations.
- Subjects
VENTRICULAR septum; HEART septum; CONGENITAL heart disease; CHROMOSOME abnormalities; GENETIC testing
- Publication
Ultrasound in Obstetrics & Gynecology, 2024, Vol 64, p67
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1002/uog.27898